Solid Snake and Otacon might be gaming's ultimate odd couple. One is a super badass secret agent clone who routinely saves the world from destruction. The other pees himself inside a closet. Regardless, the two have become good buddies and appreciate their differing skill-sets.
Uncharted has a lot of great characters, but the best duo is easily Nate and Sully. They've been friends ever since Nate was just a kid getting himself into trouble, and now they're still getting into misadventures. Even if Sully is too old for this dangerous line of work. The wisecracking friends are efficient as a team and always get the job done (even if they never get much gold).
It's always been said that man's best friend is his trusty ottsel. Okay, that has never been said, but it's an apt description for Jak and Daxter. The two duo has been through a lot together, and have also changed drastically over time, but at the end of the day they always have their buddy's back. In a world where loyalty is increasingly rare, that's noble.
Ico is a game designed around trust and friendship, so it's only natural for its lead duo to make the list. The pair holds hands through a dangerous adventure and show that all you really need in life is a good friend.
I love Persona 4 and a large reason why is due to its great cast of characters. The entire investigation team are the best of friends and it's just a joy to see them all interact with each other. It's impossible to just pick out one pairing, so the entire squad needs to be included.
While Ken and Ryu may be rivals, they are due to a mutual respect. Their competitive feud is due to an undying respect and ultimately a friendship between the two former training partners. They have so much in common (except only Ryu has a hot beard) that even their fighting styles are nearly identical.
While they start off not getting along, Joel and Ellie become like family by the end of The Last of Us. In a messed up world, they only have each other. It's an ugly truth, but also a beautiful one.
Stop me if you've heard this one before. A Lombax and a robot walk into a bar—wait, you have? Alright. Anyhow, Ratchet and Clank have a bond that gets them through thick and thin, and whatever misadventures they manage to constantly get up to.
Life is Strange is packed to the brim with interesting characters and compelling relationships, but none top the friendship of Max and Chloe. These two recently reacquainted childhood friends have changed a lot since when they used to pretend to be pirates, but still have a special kinship despite their different paths in life. It's a friendship that I'm glad I got to take a peek at, and one that is hella rad.
Not all video game friendships happen on-screen, and sometimes members of the press and game developers become friends. Both Metal Gear creator Hideo Kojima and The Game Awards' Geoff Keighley have known each other for years and have a mutual respect for each other's work. It's heartwarming to see such a great bromance in gaming.