PlayStation 2
| Name | Publisher | Week | Weekly | Total | |
| 1 | Madden NFL 10 | EA Sports | 3 | 36,983 | 230,212 |
| 2 | Mana Khemia 2: Fall of Alchemy | NIS America | 28 | 21,624 | 73,212 |
| 3 | Hakuouki: Zuisouroku | Idea Factory | 1 | 18,045 | 18,045 |
| 4 | SD Gundam G Generation Wars | Namco Bandai | 4 | 15,304 | 281,763 |
| 5 | Rock Band Country Track Pack | MTV Games | 6 | 8,625 | 49,616 |
| 6 | Guitar Hero: World Tour | Activision | 44 | 8,494 | 1,265,679 |
| 7 | Naruto Shippuden: Ultimate Ninja 4 (US and Others sales) | Namco Bandai | 23 | 8,116 | 301,769 |
| 8 | Melty Blood: Actress Again | Ecole | 2 | 8,102 | 50,274 |
| 9 | G-Force | Disney Interactive Studios | 6 | 8,071 | 44,880 |
| 10 | PES 2009: Pro Evolution Soccer | Konami | 44 | 7,967 | 2,048,747 |
| 11 | Harry Potter and the Half-Blood Prince | Electronic Arts | 9 | 7,426 | 113,674 |
| 12 | Memories Off 6: Next Relation | 5bp | 1 | 6,930 | 6,930 |
| 13 | Call of Duty: World at War Final Fronts | Activision | 42 | 6,501 | 778,972 |
| 14 | Transformers: Revenge of the Fallen | Activision | 10 | 6,282 | 175,481 |
| 15 | FIFA Soccer 09 | Electronic Arts | 48 | 6,260 | 1,911,023 |
| 16 | Kingdom Hearts Re: Chain of Memories | Square Enix | 39 | 6,055 | 382,677 |
| 17 | Resident Evil 4 | Capcom | 201 | 6,038 | 2,194,728 |
| 18 | Kamen Rider: Climax Heroes | Namco Bandai | 4 | 5,601 | 83,466 |
| 19 | NCAA Football 10 | Electronic Arts | 7 | 5,529 | 89,198 |
| 20 | J-League Winning Eleven 2009: Club Championship | Konami | 4 | 5,515 | 64,944 |
| 21 | Grand Theft Auto: San Andreas | Rockstar Games | 253 | 4,565 | 18,017,247 |
| 22 | WWE SmackDown vs Raw 2009 | THQ | 43 | 4,545 | 984,386 |
| 23 | G.I. Joe: The Rise of Cobra | Electronic Arts | 4 | 4,375 | 21,421 |
| 24 | Pro Yakyuu Spirits 6 | Konami | 7 | 4,018 | 105,490 |
| 25 | Gran Turismo 4 | Sony Computer Entertainment | 244 | 3,767 | 10,037,481 |
| 26 | Ghostbusters: The Video Game | Atari | 11 | 3,757 | 102,471 |
| 27 | The BIGS 2 | 2K Sports | 8 | 3,741 | 42,297 |
| 28 | Guitar Hero III: Legends of Rock | RedOctane | 96 | 3,680 | 4,611,696 |
| 29 | SingStar Queen | Sony Computer Entertainment | 24 | 3,614 | 133,828 |
| 30 | Trivial Pursuit | Electronic Arts | 25 | 3,577 | 110,090 |
| 31 | Lego Batman: The Videogame | Warner Bros. Interactive | 49 | 3,465 | 870,204 |
| 32 | Tiger Woods PGA Tour 10 | EA Sports | 12 | 2,832 | 73,010 |
| 33 | Indiana Jones and the Staff of Kings | LucasArts | 12 | 2,734 | 104,320 |
| 34 | NASCAR 09 | EA Sports | 64 | 2,682 | 185,990 |
| 35 | Ben 10: Alien Force | D3 Publisher | 44 | 2,584 | 271,975 |
| 36 | Shin Megami Tensei: Persona 4 | Atlus | 60 | 2,573 | 592,027 |
| 37 | MLB 09: The Show | Sony Computer Entertainment | 26 | 2,566 | 125,175 |
| 38 | Madden NFL 09 | Electronic Arts | 55 | 2,534 | 1,309,182 |
| 39 | God of War II | Sony Computer Entertainment | 129 | 2,375 | 1,826,871 |
| 40 | Guitar Hero: Smash Hits | Activision | 11 | 2,350 | 80,301 |
| 41 | S.Y.K.: Shinsetsu Saiyuuki | Idea Factory | 2 | 2,222 | 8,764 |
| 42 | Hitman Trilogy | Eidos Interactive | 40 | 2,138 | 32,425 |
| 43 | SingStar Country | Sony Computer Entertainment | 44 | 2,116 | 102,842 |
| 44 | X-Men Origins: Wolverine | Activision | 18 | 2,063 | 79,006 |
| 45 | Guitar Hero: Metallica | Activision | 20 | 1,995 | 139,310 |
| 46 | Sonic Unleashed | Sega | 41 | 1,858 | 526,963 |
| 47 | Ice Age: Dawn of the Dinosaurs | Activision | 9 | 1,846 | 21,770 |
| 48 | Lego Star Wars II: The Original Trilogy | LucasArts | 155 | 1,773 | 1,785,125 |
| 49 | SingStar Pop | Sony Computer Entertainment | 10 | 1,771 | 14,323 |
| 50 | Grand Theft Auto: Liberty City Stories | Rockstar Games | 169 | 1,771 | 1,569,212 |
[Source]
